Medicinal compound and process of making same.



UNTTES STATES PATENT OFFICEC LUDWIG OTTO IIELMERS, OF HAMBURG, GERMANY, ASSIGNOR TO THE IOII- THYOL GESELLSOHAFT, OORDES, IIERMANNI & CO., OF SAME PLACE.

MEDICINAL COMPOUND AND PROCESS OF MAKING SAME.

SPECIFICATION forming part of Letters Patent No. 649,305, dated May 8, 1900.

Application filed July 21, 1899. Serial No. 724,714:- (No specimens.)

T aZZ whom, it may concern:

Be itknown that LLUDWIG OTTO IIELMERS, a subject of the German Emperor, residing at Hamburg, in the German Empire, have in- Vented certain new an d useful Preparations of Albumin and Sulfonized Carbon Compounds and Process of Making Same, of which the following is a specification.

Albumin solutions are not precipitated by To the salts of ichthyolsulphonic acid from a sufiiciently-diluted solution, even when the said solution is heated to boiling-point. Like the ichthyol salts in the presence of albumin also behave other substances which are obtained by the action of sulfuric acid on mineral oils and similar hydrocarbons containing sulfur-viz.,theso-called petrosulfol, (see lViencr K limsche Rzmdschau, No. 20, 1898,) thiol, (see German Patent No. 38,416.) and the like. According to the German Patent No. 100,707 precipitations from these solutions take place only in the presence of a stronger acid, respectively, by employing free sulfonic acids. Experiments, however, have shown that such precipitations containing al- 'bumin can also be obtained by an addition of sufficient quantities of salt to the watery solutions of albumin and the aforesaid sub stances. The precipitations obtained at ordinary temperature by the alkali salts are in contrast to the substances obtained by the German Patent No. 100,707 soluble in pure water. They become insoluble by drying and heating for a somewhat longer time with a salt solution in excess. These products, in-

soluble in water, can be obtained directly by producing the precipitation at a higher temperature. Some salts, such as sodium phosphate, precipitate solutions of albumin and the said sulfur-containing substances only by heating. WVhen treating such albumin solutions with salts of the earth alkalies or with salts of metals, it will notbe necessary to heat the solution, since precipitations insoluble in water take place at ordinary temperature, so that they need only be washed out and dried. The substances thus obtained in one or the other way by precipitationwith salts contain, besides the sulfonic acids and albumin, also the base of the salt utilized, and therein are different from those described in the German Patent No. 100,707. These new chemical compounds are precipitated in the form of slimy products containing water, which after drying at about 100 cenligrade are easily pulverizable and are of a brown color without smell or taste, insoluble in water, and nearly insoluble in the usual organic solvents. By heating them with acids they split off the base, and thus become converted into the products of the German Patent No. 100,707. When being heated with alkali, they swelland grad ually become completely dissolved.

The following is given as an example of the process: (a) One kilogram of petrosulfol is dissolved in three liters of water and then added to a solution of one kilogram of albumin in ten liters of water. This mixture is precipitated by gradually stirring it with twentykilograms of a temper-cent. ammouium-chlorid solution.

After the precipitation is completed the liquor containing albumin and ammonium c1110- rid is poured off, and to the precipitated residue is added a solution of ammonium chlorid, which is then heated for several hours, and afterward the insoluble precipitation is pressed and washed in hot water and finally dried at about 100 and pulverized.

(b) To the solution of one kilogram of thiol 8o in twenty liters of water is mixed onekilogram of albumin in ten liters of water, and the mixture is then heated for some time over a water-bath by adding twenty kilograms of a twenty-five-per-cent. common-salt solution. 8 5 The liquor is then poured off and the precipitation is repeatedly washed with water,pressed, and dried.

(c) The solutions of one kilogram of ichthyol ammonium in fifteen liters of water and go one kilogram of albumin in ten liters of water are precipitated with three kilograms of a tenper-cent. calcium-chlorid solution. The precipitation is freed of its liquor by pressing and afterward washed with water and dried.

Having fully described my invention, what I claim, and desire to secure by Letters Patent, is-

1. The process which consists in treating an aqueous solution of a mixture of albumin, I00 and a product derived from a sulfuret'ed hydrocarbon combined with sulfuric acid, with a solution of a suitable salt, whereby an inpound being insoluble in Water and other soluble compound is formed and precipitated, solvents and tasteless as Well as odorless, subsubstantially as set forth. stantially as set forth.

2. A compound in the form of a brown pow- LUDWIG OTTO HELMERS. 5 der, consisting of albumin, a base, and a Witnesses:

product derived from asulfuretedhydrocar- ALEXANDER SPEOHT,

bon combined with sulfuric acid, said com- E. H. L. MUMMENHOFF. 

